Protective and Prophylactic Role of Brassicaceae Vegetables Extracts on N-nitrosodiethylamine Induced Initiation of Hepatocellular Carcinoma in Rat Liver

Nitroso compounds and their precursors in the environment, in certain occupational settings, in diet and also due to the use of tobacco products, cosmetics, pharmaceutical products as well as their endogenous formation in the human body from dietary components, may be potential risk factors in cancer, Nitrosamines, such as, N-nitrosodiethylamine (NDEA), one of the most important environmental carcinogen of this class, has been suggested to cause the generation of reactive oxygen species (ROS) resulting in oxidative stress and cellular injury [1]. As liver is the main site of NDEA metabolism, the production of ROS in liver may be responsible for its carcinogenic effects.